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Dreyfus Appreciation (DGAGX)
1-year return: -3.5%
5-year return: 8.1%
Expense ratio: 0.95%
ETF alternative: iShares S&P Global 100 Index (IOO)

With today's uncertainty, you may want to take refuge in blue chips. That's where Dreyfus Appreciation stands out. This large-cap fund's portfolio is a who's who of multinational giants, which fund manager Fayez Sarofim favors for growth potential and protection in downturns. As he puts it, "The rest of the world is more than making up" for the U .S. economy's weakness. The fund boasts minimal turnover and low volatility and has generated 10.4% average returns since 1990. A n ETF with a megacap focus, like the iShares S&P Global 100 Index, offers a similar slate.

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Last updated June 20 2008: 2:34 PM ET
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